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Regulation of the Kruppel-like Factor 6 Tumor Suppressor
Engleski
189 b
30 dana za povrat kupljenih proizvoda
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KLF6 is a ubiquitously expressed Krüppel-like§transcription factor whose role in vitro and in vivo§role has not been fully identified. Like other§members of the Krüppel-like family, KLF6 contains a§conserved C-terminal three zinc finger DNA-binding§domain (C2H2 motifs) and a unique N-terminal§transactivation domain. KLF6 directly binds DNA at GC§box promoter elements. Transcriptional targets of§KLF6 include collagen 1, transforming growth factor§beta 1 (TGF 1), types I and II TGF receptors,§urokinase type plasminogen activator (uPA), and the§human immunodeficiency virus long terminal repeat§(HIV-1 LTR). Here, we identify a novel mechanism of§carcinogenesis, whereby oncogenic Ras signaling§enhances alternative splicing-mediated inactivation§of the KLF6 tumor suppressor in hepatocellular§carcinomas. These Ras-dependent splice forms are§shown to abrogate KLF6-mediated growth suppression,§and ectopic KLF6 splice variant expression can§restore a Ras-transformed phenotype.
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