QSAR Study of Potent Gsk-3beta Inhibitor for Type II Diabetes

This is a best book for analyzing 2D QSAR technique for determining the potent GSK-3beta inhibitor against diabetes.Computer-aided drug design is a branch of medicinal/computational chemistry and is of great interest now a day. Computer-aided design of chemical compounds with controlled properties is generally performed using computer-aided design systems.Its becoming increasingly involved in understanding the differences between potent molecules and drug candidates (ADMET-absorption, distribution, metabolism, excretion and toxicity) this is already fueling a rise in impact and expectations for CADD. The use of quantitative structure-activity relationships (QSAR) has become increasingly helpful in understanding many aspects of chemical-biological interactions in drug and other scientific research. In the present effort, we exaggerate our pursuit of being establishing the relationship between the various physiochemical parameters and anti-diabetic activity of 3-aryl- 4-(arylhydrazono)-1H pyrazol-5-ones derivatives by using classical quantitative structure- activity relationship (QSAR) descriptors and similarity indices.