New Approaches in Cancer Pharmacology: Drug Design and Development

This monograph is the first of two dealing with selected§topics in the area of the design and development of new§anticancer drugs. Its purpose is to present a collection of§opinions from international experts in the field, with the§aim of stimulating the further development of new drugs on a§rational basis. The topic is treated in a lively way. The§reviews focus on the very latest developments in key areas,§concentrating on the exciting developments, controversies§and future trends. They are not long histrical reviews, but§nevertheless do provide the appropriate background and§references. However, emphasis is on the state of the art. In§this respect the approach is quite different from other§books in the area. Readers, including particularly§scientists and doctors interested in cancer drug, will find§this useful as an up to date source of current opinion and§debate. It will be suitable for experts in the field, but§also accessible to research students for example. They§should find it a valuable reference for the latest§developments and particularly the controversial areas in the§field. It is designed to promote and encourage further§debate and to influence the research community. The§particular topics covered are:§DNA sequence and gene specific drugs - Antisense and§antigene oligonucleotides targeted to oncogenes - Prospects§of biological and gene therapies - Membrane and signal§transduction targets - Design of novel anti-endocrine agents§-Therapeutic monitoring and dose optimization in oncology -§Screening for new anti-tumour drugs