Modeling in Biopharmaceutics, Pharmacokinetics and Pharmacodynamics

The state of the art in Biopharmaceutics, Pharmacokinetics, and§Pharmacodynamics Modeling is presented in this new second edition book. It§shows how advanced physical and mathematical methods can expand classical§models in order to cover heterogeneous drug-biological processes and§therapeutic effects in the body.§§The book is divided into four parts; the first deals with the§fundamental principles of fractals, diffusion and nonlinear dynamics; the§second with drug dissolution, release, and absorption; the third with§empirical, compartmental, and stochastic pharmacokinetic models, with a new§chapter on bioequivalence; and the fourth mainly with classical and nonclassical§aspects of pharmacodynamics. The§classical models that have relevance and application to these sciences are also§considered throughout. This second§edition now has new information on time-varying models and interface models.§Many examples are used to illustrate the intrinsic complexity of drug§administration related phenomena in the human, justifying the use of advanced§modeling methods.§§This book will appeal to graduate students and researchers in§pharmacology, pharmaceutical sciences, bioengineering, and physiology.§§Review of the first edition:§§"This book presents a novel§modelling approach to biopharmaceutics, pharmacokinetics and pharmacodynamic§phenomena. This state-of-the-art volume will be helpful to students and§researchers in pharmacology, bioengineering, and physiology. This book is a§must for pharmaceutical researchers to keep up with recent developments in this§field." (P. R. Parthasarathy, Zentralblatt MATH, Vol. 1103 (5), 2007)§