Leukemia-lymphoma Cell Line Factsbook

This book represents an essential reference manual for all of the well-characterized leukemia-lymphoma cell lines currently available. It provides the most important facts, using the succinct and user-friendly format that has made the "FactsBooks" so popular with scientists and clinical researchers. Introductory chapters provide background and perspective for culturing malignant hematopoietic (blood forming) cell lines. These chapters are followed by over 400 comprehensive individual entries. Each cell line entry highlights essential clinical, immunological, genetic, and functional features and includes a comprehensive listing of references. Key features include: the full spectrum of malignant cell lines from all hematopoietic cell lineages; sister cell lines and relevant subclones; clinical data such as: patient, diagnosis, treatment status, and specimen source; authentication of derivation and availability; immunophenotype; cytogenetic karyotype; translocations and fusion genes; receptor gene rearrangements and genetic alterations; cell cultures aspects: establishment, medium, doubling time, and growth; cytochemical profile; cytokine production and response to cytokines; proto-oncogene and transcription factor expression/alteration; functional features such as: differentiation induction, heterotransplantability; special unique features; and key references.