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Drawing on their collective and respective expertise, the Editors and contributing authors are developing a handbook project on two intersecting modern problems: infectious disease informatics and biosurveillance. Infectious Disease Informatics (IDI) is a field that has emerged from biomedical informatics. Biosurveillance is an IDI application focusing on monitoring for new outbreaks of infectious diseases. Both areas are closely related and they have significant practical implications in the globalized world we live in.§INFECTIOUS DISEASE INFORMATICS AND BIOSURVEILLANCE: A Handbook of Research, Systems and Case Studies will be a systematic combined work which will accomplish the following: (1) provide structure to the multidisciplinary research in this fast moving, dynamic field, (2) define and further build the field, and (3) create an authoritative reference book for researchers, students and practitioners in the field.