Allopurinol & Garlic Oil Intake In Renal Failure Rats

Several studies in man and experimental animals have clearly documented the progressive accumulation of aminoglycosides in the prilymph and enolymph in the inner ear. Gentamicin is a nephrotoxic agent that caused acute renal failure in experimental animals. The specificity of its toxicity is related to its accumulation in the renal proximal convoluted tubules, enhancing the production of hydrogen peroxide. Allopurinol (Allo.) is an inhibitor of xanthine oxidase and prevent the conversion of hypoxanthine and xanthine to uric acid and subsequent free radical that primarely cause tissue injury. Inhibition of this enzyme accounts for the major pharmacological effects of Allo. It's treatment increases the levels of glutathione peroxidase in the kidney tissues suggesting its beneficial effects against renal injured rats. Nevertheless, it still has a toxic effect on liver and other tissues in the body. Garlic 'a secret miracle of GOD' belongs to the oldest traditional medicinal plants. It has already been mentioned 1500 A.D. in an ancient Egyptian medical script, the Papyrus Ebers. It is used as a medicine since the time of Hippocrates. It has also been used in folk medicine.